Thursday, November 10, 2005

New STUDY SHOWS COMPELLING EVIDENCE OF major intestinal immune disease
in children with autism

Thoughtful House scientists and collaborators confirm link between autism
and new inflammatory bowel disease

Austin, Texas - In a study that provides further clues to understanding
the origins of autism, scientists and physicians from Thoughtful House
Center for Children in Austin, Texas, supply considerable evidence of
a new
inflammatory bowel disease in children with autism. The study will be
published this month in the European Journal of Gastroenterology and
Hepatology. (this is posted at http://thoughtfulhouse.org/pub_06.htm)

The team studied 178 children undergoing intestinal investigation for
gastrointestinal symptoms such as diarrhea and abdominal pain. More than
140 of these children also had autism, most having regressed after normal
early development. The children with autism had an increased rate of
swelling of the intestinal lymph glands (lymphoid nodular hyperplasia) - a
feature of viral infections and immunodeficiency diseases such as AIDS.

Additionally, the children with autism experienced associated inflammation
of the intestinal lining, while the children examined in the study without
autism did not. The degree of swelling of the intestinal lymph glands was
also more severe in children with autism compared with developmentally
normal children.

"The results of this study give us additional clues on understanding what
is going on in the gut and how it may lead to the brain disorder,"
says Dr.
Andrew Wakefield, Executive Director of Thoughtful House and the lead
author on the paper. "We are working on the idea that what starts in the
intestine can be severely disruptive to normal brain development."

The paper dispels the common misconception that the presence of swollen
lymph glands is a normal finding in children.

"When we compare the intestinal findings in children with and without
autism in a systematic way, the differences become obvious," says Dr.
Wakefield, "Colonoscopies are not performed on normal children, but on
children with gastrointestinal symptoms, so it is not possible to state
that this is a normal finding. The findings of this new study add to the
clear evidence of a novel and treatable disease of the intestinal immune
system in children with developmental disorders. These are medical
diseases
which should be treated as such. Children are suffering needlessly and
this
has got to change."

The presence and severity of the swollen lymph glands was not influenced
by exclusion diets that some children were on, suggesting that food
allergy
or intolerance was not the cause. The fact that these children also have
abnormal immune systems and the resemblance of the disease to the
intestinal findings in some patients with HIV infection suggests the
disease may be associated with a smoldering viral infection.

"This study, in combination with previous work, raises the possibility
that treating bowel disease may alleviate some of the symptoms of autism
itself," says Dr. Wakefield. "This is something Thoughtful House will be
putting to test in the near future."


--------------------------------------------------------
Sheri Nakken, R.N., MA, Classical Homeopath
Vaccination Information & Choice Network, Nevada City CA & Wales UK
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